The population level effectiveness of a vaccine may arise as the result of direct protection of vaccines and vaccine herd protection, which may protect non-vaccines, vaccines, or both. Indirect, total, enhanced, and overall vaccine protection are measures of vaccine herd protection. The level of population level effectiveness induced by a vaccine is driven by several factors, including known vaccine-induced protective efficacy, the magnitude, and distribution of vaccine coverage at a point in time and the extent to which different groups mix with one another in the community. Data on vaccine herd protection are valuable in understanding the importance and cost-effectiveness in deploying the vaccine in public health program. This presentation provides a brief description of the herd protective effects of the oral cholera vaccines, as an example, that have been evaluated for herd protection in various study settings, leveraging the geographic information system (GIS) tools for analyses. The study designs include individually randomized clinical trials, cluster randomized clinical trials, observational cohort studies, and observational case-control studies. In all study designs, significant herd protection was observed in unvaccinated persons as well as in the community as a whole. The findings of these studies suggest that use of the GIS tools may effectively assess population level vaccine effectiveness in different study designs.
Who is this event intended for? Statisticians working in vaccines.
What is the benefit of attending? Attendees will have the opportunity to learn about statistical methods.
16:00 BST | 17:00 CEST | 11:00 EDT